BLOOD TEST · SMART CARE POLYCLINIC, DEIRA
Bilirubin explained
The yellow pigment the liver clears from blood, reported as a total and a direct fraction.
What the Bilirubin test measures
What is left when old red blood cells break down. The liver processes it so it dissolves, then sends it out in bile. Which of the two fractions is raised is the whole point of measuring both — it separates a harmless inherited pattern from a blockage or liver injury.1
Reported as part of Liver Function Test.
What the result tells you
Total up, direct normal
In a well person this is most often Gilbert's syndrome — a harmless inherited variation needing no treatment, most visible when fasting or run down.
The other cause of that pattern
Faster breakdown of red blood cells, which the blood count helps identify.
Direct fraction raised
This matters more. Bilirubin was processed but cannot get out — pointing at liver cells or an obstruction in the bile ducts. ALP and ALT decide which.
When it becomes visible
Yellowing of the whites of the eyes appears once it rises well above normal. Below that it is silent, which is why it is measured.
How to prepare
- Fasting
- Not needed, but usually taken with a fasting panel
- Best time
- Morning, with the rest of the panel
- Worth knowing
- Prolonged fasting genuinely raises bilirubin in people with Gilbert's syndrome — say so if you fasted longer than asked.
What can move the result
A result outside the usual range does not on its own mean something is wrong. These are the everyday explanations a doctor considers first.
Frequently asked questions
What is left when old red blood cells break down. The liver processes it so it dissolves, then sends it out in bile. Which of the two fractions is raised is the whole point of measuring both — it separates a harmless inherited pattern from a blockage or liver injury. Total up, direct normal: In a well person this is most often Gilbert's syndrome — a harmless inherited variation needing no treatment, most visible when fasting or run down.
Fasting: Not needed, but usually taken with a fasting panel. Best time: Morning, with the rest of the panel. Prolonged fasting genuinely raises bilirubin in people with Gilbert's syndrome — say so if you fasted longer than asked.
Commonly: gilbert's syndrome, common and harmless; prolonged fasting or recent illness, in people who have it; faster breakdown of red blood cells; obstruction of the bile ducts, including gallstones; liver inflammation from any cause. A single result is not a diagnosis. Values are read against the laboratory's own reference range and alongside your history, your symptoms and the rest of the panel — which is why every package includes a doctor to go through them with you.
At Smart Care Polyclinic, 29 Doha Centre, Al Maktoum Rd, Deira, Dubai. Walk in during opening hours or call +971 (0)4 379 3562.
Sources
Written from current guidance and reviewed 31 August 2026.
Sources cited above
- Kwo PY, Cohen SM, Lim JK. ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries. The American Journal of Gastroenterology. 2017;112(1):18-35. PMID 27995906. doi:10.1038/ajg.2016.517The American College of Gastroenterology guideline on what a raised liver enzyme actually means and how an abnormal result should be worked up.
Sources are listed for the specific statements they support. They are published research and guidance, not a substitute for a consultation — what applies to you is decided by a doctor who has assessed you.
- Bilirubin blood testMedlinePlus, US National Library of Medicine
- Jaundice and Gilbert's syndromeNHS
- Evaluation of abnormal liver chemistriesAmerican Association for the Study of Liver Diseases